vial
500mg (10mL)
NAD+
NAD+ (nicotinamide adenine dinucleotide) is a central metabolic coenzyme that research explores for its role in cellular energy production, DNA-repair signaling, and the biology of aging. Physician-supervised NAD+ protocols are studied for supporting mitochondrial function and resilience to age-associated metabolic decline.
Mechanism of action
How researchers describe NAD+ working at the receptor, signaling, neural, and regulatory levels. Mechanistic and investigational — shared to inform, never to promise an outcome.
Receptor Activation
Unlike peptides that bind a single cell-surface receptor, NAD+ acts primarily as a coenzyme and signaling substrate rather than a classical receptor agonist. Research associates its extracellular and salvage-pathway dynamics with purinergic signaling and with NAD+-consuming enzymes such as CD38 and CD157, and study models describe transport into cells where it becomes available to intracellular targets. Its activity is therefore best understood as substrate-level engagement of enzymatic machinery rather than direct receptor activation.
Cell Signaling
In study models, NAD+ serves as an obligatory cofactor for the sirtuin family (notably SIRT1 and SIRT3) and for PARP enzymes involved in DNA-damage response, linking its availability to deacetylation signaling and genomic-maintenance pathways. Research suggests that the cellular NAD+/NADH ratio influences redox balance and mitochondrial biogenesis, with effects associated with downstream regulators such as PGC-1α and AMPK. These connections position NAD+ as a node coupling metabolic state to transcriptional and repair signaling.
Neural Activity
Research explores NAD+ in the context of neuronal energy metabolism and axonal maintenance, where preclinical models associate NAD+ availability with protection against metabolic stress in neural tissue. Some study pathways implicate NAD+ biosynthesis (via NMNAT enzymes) in axon resilience, though direct receptor-mediated neuroactivity is not the primary described mechanism. Its CNS relevance is generally framed around supporting cellular energetics rather than acting as a conventional neurotransmitter.
Regulatory Pathways
NAD+ is associated in research with systemic metabolic regulation, including roles in glucose and lipid handling through sirtuin- and AMPK-linked pathways. Study models also connect NAD+-consuming enzymes such as CD38 to immune-cell signaling and inflammatory tone, and declining NAD+ levels have been associated with age-related metabolic and circadian changes. These observations frame NAD+ as a regulator of energy homeostasis studied within a broader healthy-aging context.
Built around you, never one-size-fits-all
Who it's for
A physician may consider NAD+ for an adult focused on healthy-aging, cellular energy, and metabolic resilience goals who is seeking a supervised, mechanism-based wellness protocol rather than treatment of a specific disease.
What's included
Includes one 500mg/10mL NAD+ vial, a licensed physician evaluation to assess appropriateness, and personalized dosing and administration guidance.
More information
A valid health screening is required before any order is fulfilled. After checkout you will receive instructions to complete the required intake. Orders are processed only once a licensed physician has reviewed and approved your screening. Each completed screening remains valid for 12 months.
- Personalized guidance, one-on-one with your care team.
- Full refund if a licensed physician determines the treatment isn't a fit.
Purity you can verify
Most peptides sold online are imported, unverified, and labeled to dodge the rules. We built the opposite — American-made, properly tested, and physician- supervised on every order.
- Manufactured in U.S. cGMP-registered facilities
- Every batch third-party tested with a Certificate of Analysis
- Reviewed and prescribed by U.S.-licensed physicians
- Cold-chain handling and discreet, tracked delivery
Related therapies
Begin NAD+ with a physician evaluation
One honest price, evaluation included. A licensed physician reviews your case before anything ships — with a full refund if it isn't the right fit.